Therefore, to clarify the relationship between GSCs chemoresistance and METTL3-mediated m6A modification, we detected the expression of METTL3 and m6A modification in both GSCs and corresponding differentiated tumor cells and confirmed that METTL3 promoted GSCs resistance to TMZ via increasing MGMT and APNG in a m6A-dependent manner. Here, MPG is linked to neoplasm.