FSTL3 and neoplasm: Moreover, multiple potent signaling molecules were identified in the secretomes of Meso-CAFs like the lymphangiogenesis inducer VEGFC [49] or the activin antagonist follistatin-like 3 (FSTL3) [50] that, in addition to directly affecting tumor cells, could have impacts on non-malignant cells in the TME and influence angiogenesis or immune responses.