UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: To examine whether MUC1 influences Ca homeostasis in humans, plasma Ca was assessed in individuals with one working copy of MUC1. Autosomal dominant tubulointerstitial kidney disease can occur as a consequence of a frame-shift mutation in MUC1 (ADTKD-MUC1) or mutation in the gene encoding uromodulin (UMOD, ADTKD-UMOD) (17).