IL6 and osteoarthritis: Next, by further analysis of ten hub genes (MYC, JUN, DUSP1, NFKBIA, VEGFA, ATF3, IL-6, PTGS2, IL1B and SOCS3), we discovered that MYC, JUN, DUSP1 and NFKBIA were specifically expressed in the immune system and selected as biomarkers and potential therapeutic targets in osteoarthritis.