Synovial membrane tissue in normal control had a high abundance of resting memory CD4 T cells (p < 0.001), activated NK cells (p = 0.007), activated mast cells (p < 0.001) and eosinophils (p = 0.021), while in osteoarthritis patients, the high infiltrating abundance of resting mast cells (p < 0.001), B cells memory (p = 0.003) and plasma cells (p = 0.001) were observed (Fig. 2C). The gene discussed is CD4; the disease is osteoarthritis.