CHD4 and ovarian cancer: Notably, CHD4 depletion sharply reduced the viability (p < 0.05 at 48 h; p < 0.001 at 72 h and 96 h) (Fig. 2C) and metastasis-related behaviour (Fig. 2D) of ovarian cancer cells, suggesting that CHD4 is required to maintain the metastases of ovarian cancer cells.