In 2019, European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) classified SLE based on positive ANA as an obligatory criterion; in addition to seven clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and three immunological (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) domains, and clarified a scoring system of a “weight from 2 to 10.” A patient who has ≥ 10 points will be classified as SLE [13]. Here, BTG3 is linked to systemic lupus erythematosus.