7-Methylguanosine is also linked to chemotherapy resistance in tumors, and METTL1 is the most representative enzyme mediating methylation within m7G, which works in concert with its cofactor, WD repeats structural domain 4 (WDR4), to mediate methylation [12].and its mediated 7-methylguanosine (m7G) is essential for the regulation of chemoresistance in cancer therapy [17]. This evidence concerns the gene METTL1 and cancer.