Additional cluster 3 proteins categorized to cardiomyopathy and sarcomeric proteins exposed to constant mechanical stress, including Desmin (DES), dystrophin muscular dystrophy (DMD); myosin binding protein C, cardiac (MYBPC3); myosin light polypeptide 2 (MYL2); Titin (TTN) and phospholamban (PLN) (Fig. 3B, C and Supplementary Fig. 7A). This evidence concerns the gene DES and cardiomyopathy.