LEP and obesity due to melanocortin 4 receptor deficiency: We performed global circRNA expression profiling in pancreatic islets obtained from two mouse models of obesity—HFD-fed mice compared to normal chow diet (NCD)-fed mice and mice homozygous for the obesity-related mutation of leptin (Lepob/ob) compared to wild-type littermates—to identify circRNAs potentially contributing to the development of obesity-associated disturbances in β-cell dysfunction and apoptosis.