TH and Parkinson disease: In conclusion, this study shows that CPT1A P479L mutant mice are resistant to rotenone-induced PD, and that inhibition of CPT1 using etomoxir restores some aspects of motor and non-motor function, LDL-c/HDL-c ratio, TH levels, possibly decreases α-syn deposition and reduces gene expression of reactive microglia/macrophage markers in the midbrain in C57Bl/6J mice exposed to rotenone.