We found that PARK2+R mice had significantly lower spontaneous alternation percentage in the Y-maze test (54 ± 35.4 range) compared to none-exposed mice (66.1 ± 3.95 SEM, p = 0.003) (Fig. 7g), which indicated that the cognitive impairment was further exacerbated by rotenone. This evidence concerns the gene PRKN and Cognitive impairment.