However, when AST-treated AD cell models were cotreated with autophagy inhibitors 3-MA or bafilomycin A1 (Baf A1), the ratio of LC3BII/LC3BI and the expressions of Beclin-1 and LAMP-1 were significantly reduced (Fig. 7B, C, E–H, J, K) while the expression of p62 was significantly increased (Fig. 7B D, G, I). The gene discussed is BECN1; the disease is Alzheimer disease.