In summary, these data show that overexpression of a single chRCC master transcription-factor candidate, FOXI1, in the ccRCC cell line 786-O, with or without knockdown of EPAS1, led to marked expression changes driving the cell line to be more like a chRCC cell line without any modification to the set of mutations present in 786-O cells. The gene discussed is FOXI1; the disease is chromophobe renal cell carcinoma.