In our dataset, loss-of-function single-nucleotide variant and copy number alterations (see “Methods”) in such commonly mutated genes in RCC (VHL, PBRM1, BAP1, and TP53) did not correlate with global acetylation differences in both supervised and unsupervised analyses, albeit the small sizes were small. The gene discussed is PBRM1; the disease is renal cell carcinoma.