The FOXI1 OE/EPAS1 KD 786-O cell line demonstrated significantly higher expression of chRCC-specific candidate master TFs, TFCP2L1, GATA2, DDIT3, NKX6-1, and lower expression of ccRCC-specific candidate master TFs, ZNF395 and TSC22D3. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.