Concomitant FOXI1 OE and EPAS1 KD in 786-O cells resulted in upregulation of chRCC-specific master TFs such as TFCP2L1 and NR3C2 and down-regulation of ccRCC-specific master TFs such as ETS-1 and ZNF395 compared to control cells. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.