Analysis of 11 primary, 21 metastatic ccRCC samples, and 11 normal renal tissue samples showed that tumors with homozygous C/C alleles were significantly enriched for EPAS1 peaks (Fig. 5E, F) in both tumors and normal tissue and that rs4903064 is a EPAS1 cQTL. This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.