This analysis highlighted 50 candidate histology-specific master TFs (N = 20, chRCC; N = 14, pRCC; N = 16, ccRCC) (Supplementary Data 12), including FOXI1, TFCP2L1, and DMRT2 for chRCC; EPAS1, ETS1, BARX2, ZNF395 for ccRCC, and HNF1B and NR2F2 for pRCC (Fig. 3B). The gene discussed is TFCP2L1; the disease is nonpapillary renal cell carcinoma.