ETS1, in the bZIP family with BATF, has been implicated in von-Hippel Lindau (VHL)-dependent ccRCC tumorigenesis37, and was highly marked by H3K27ac in ccRCC, less so in pRCC, and not in chRCC (Fig. 2I). The gene discussed is PRCC; the disease is nonpapillary renal cell carcinoma.