EPAS1 and nonpapillary renal cell carcinoma: Defining chRCC and ccRCC gene sets as the top 100 upregulated genes for each histology relative to the other, we showed that the chRCC gene set is enriched among upregulated genes in 786-O FOXI1 OE/EPAS1 KD cell line vs. control (Fig. 4E), and the ccRCC gene set is enriched among upregulated genes in 786-O control vs. FOXI1 OE/EPAS1 KD cell line (Fig. 4F).