Motif enrichment analysis of putative ccRCC-specific enhancers identified a motif resembling the basic Leucine Zipper (bZIP) BATF motif, and another resembling the basic helix-loop-helix (bHLH) TF family member HIF2α (also known as EPAS1) (Fig. 2H). Here, TF is linked to nonpapillary renal cell carcinoma.