ETS1, in the bZIP family with BATF, has been implicated in von-Hippel Lindau (VHL)-dependent ccRCC tumorigenesis37, and was highly marked by H3K27ac in ccRCC, less so in pRCC, and not in chRCC (Fig. 2I). This evidence concerns the gene ETS1 and nonpapillary renal cell carcinoma.