EPAS1 and nonpapillary renal cell carcinoma: We overexpressed FOXI1 in the ccRCC cell line 786-O (FOXI1 OE); suppressed EPAS1 (EPAS1 KD) and simultaneously perturbed both genes in the same cell line (FOXI1 OE/EPAS1 KD) (Supplementary Fig. S7C–7E and Supplementary Data 14).