We selected four representative master TFs that met the following criteria: (1) at least twofold change in gene expression of the histology-specific TF by bulk RNA sequencing (from TCGA) compared to the two other RCC histotypes, (2) high-quality antibodies for IHC, and (3) TF was not previously validated and implemented on a clinical level. This evidence concerns the gene TF and renal cell carcinoma.