HIF1A and Sepsis: Interestingly, our bioinformatics analyses (Fig. S5) and literature [28] showed that both miR-150-5p and miR-21-5p modulated HIF-1 cellular signaling pathway, whilst the HIF-1α signaling pathway was shown to be attributable to the immunosuppression through the immune cell (e.g., monocytes) phenotype changes reprogramming in the late stage of sepsis.