NFKB1 and Parkinson disease: Regarding the potential mechanisms linking NF-κB alterations to PD, previous studies have shown that NFKB1 is regulated by the PRKN gene (Parkin), which harbors mutations associated with familial forms of PD110, and that NFKB1 activity is also modulated by STAT3111 (see the discussion of STAT3 above).