CD8A and COVID-19: Compared with influenza- or respiratory syncytial virus-specific cells, the expression of glycolysis-related genes were found to be decreased in SARS-CoV-2-responsive CD8 + T cells, which was associated with reduced CD8 + T cell polyfunctionality.34 In addition, metabolic reprogramming, induced by activation, is damaged in CD8 + T cells from COVID-19 patients.35 Specifically, in vitro–activated T cells from patients with COVID-19 displayed the decrease of glycolytic capacity and reserve, coupled with the relatively low activated mTOR signals.