SERPINE1 and cancer: Following our findings on both intracellular and extracellular SERPINE1 may be important for DSB repair in cancer cells, we attempted to deplete SERPINE1 in MDA-MB-231 cells or in hAd to obtain hAd-CM with low level of SERPINE1 (Fig. S6A) to clarify whether cancer cell autonomous or non-autonomous SERPINE1 is important for establishing radioresistance.