In our DIO syngeneic mouse model, the serum level of Serpine1 was positively correlated with tumor mass (Fig. 2C), and Serpine1 was also abundant within the tumor microenvironment in HFD groups (Fig. 2D), implying that the adipocyte-secretome including SERPINE1 may enhance SERPINE1 expression and secretion in cancer cells. This evidence concerns the gene SERPINE1 and cancer.