Indeed, based on our results from the transwell migration assay, the obesity-mimicking condition was able to promote migration of TNBC cells, and the phenomenon was dampened after SERPINE1 depletion, pinpointing a critical role for SERPINE1 in obesity-promoted cancer cell migration (Fig. 5). The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.