Furthermore, monoclonal antibodies directed against Lea (Fig. 12D) and Leb (Fig. 12E) determinants were mainly bound to the fractions obtained from pooled tumor tissues (Fig. 12, D and E, lane 2), which confirmed the higher amounts of Lea pentosylceramide (Lea-5) and Leb hexosylceramide (Leb-6) detected by LC/ESI-MS2 in the tumors. The gene discussed is MUC5AC; the disease is neoplasm.