This randomized trial showed that the combination therapy of gefitinib plus chemotherapy (carboplatin + pemetrexed) had significantly improved Objective Response Rate (ORR) (84% vs. 67%), PFS (20.9 vs. 11.9 months) and OS (50.9 vs. 38.8 months) as compared with gefitinib alone in 345 patients with newly diagnosed metastatic NSCLC with EGFR mutations.18 This evidence concerns the gene EGFR and non-small cell lung carcinoma.