Since the discovery of SARM1 as the main trigger of axonal degeneration in classic models of WD,42,77,78 there has been a great drive to discern whether Sarm1 deletion may also attenuate acute or chronic axonal pathology and degeneration in disease-related scenarios, including TAI.73 Our results confirm the central role of SARM1 in traumatic axonopathy and further clarify the cellular and temporal details of its involvement. The gene discussed is SARM1; the disease is Wilson disease.