Indeed, while T-cell responses against structural and non-structural SARS-CoV-2 proteins in the convalescent phase of mild COVID-19 are similar in PLWH with cART-suppressed HIV viral load and HIV-negative subjects overall, the magnitude of SARS-CoV-2–specific T-cell responses is positively related with the CD4/CD8 ratio and the size of naïve CD4 T-cell pool in PLWH [58••]. This evidence concerns the gene CD4 and COVID-19.