Several studies have shown an association between CHIP status and mortality in cardiovascular diseases, specifically in patients with atherosclerosis [2], heart failure of both ischemic and non-ischemic cause [3, 14–16], stroke [17] and, as now demonstrated in the present study, severe aortic stenosis even after removal of the stenotic valve by TAVR. The gene discussed is STUB1; the disease is aortic stenosis.