CCN2 and Strabismus: Zhu et al. (2013) found reduced expression of seven myogenesis-related genes in EOMs of patients with concomitant strabismus [45], and Agarwal et al. (2016) reported downregulation of muscle proteins and upregulation of expression of collagens, regulators of collagen synthesis and degradation, connective tissue growth factor (CTGF), and growth factors controlling extracellular matrix (ECM) [46].