P53 expression was downregulated in both B-ALL (0.4-fold, ns)and T-ALL (0.3-fold, P<0.01) patients along with upregulation ofc-Myc in B-ALL (3-fold, P<0.01) and T-ALL (7-fold,P<0.001) patients (Fig .1C, D). This evidence concerns the gene MYC and acute lymphoblastic leukemia.