CD8A and neoplasm: B7-H3 is now assumed to have a predominantly inhibitory role, suppressing T-cell activation and B7-H3 on DC reduces CD4+ and CD8+ T-cell activation, as well as effector cytokine release by inhibiting the expression of major transcriptional factors, such as NF-κB, while expression in tumour cells has been shown to suppress NK cell activation [53,54].