AFP and hepatocellular carcinoma: By univariate analysis, male gender, age, alcohol use, high LSM values, presence of non-characterized liver nodule, presence of ascites, time since pretreatment imaging, serum albumin < 3.5 g/dL, platelet count < 100,000 mm3, AFP > 10 ng/mL, high INR, elevated bilirubin and alkaline phosphatase, genotype 1, and lack of response to DAA treatment were significantly associated with development of HCC after DAA treatment.