Increased levels of LDH were detected in the cell culture supernatant of HAdV-5-HexPos3-E1A-Δ24-E1B-Δ19K-infected hMSCs from 48 h onwards compared to hMSCs infected with the other replication-competent vectors, corresponding to an accelerated release of viral progeny upon infection with E1B-Δ19K-modified vectors. The gene discussed is DHTKD1; the disease is infection.