Conversely, immunological status described by CD4+ nadir and CD4+ cell count at the time of the 2DR-3TC switch was confirmed: the lower CD4+ nadir value, which tends to be lower in HbcAb-positive than negative patients (222/mm3 [IQR 69–335], p = 0.023), describes a more severe baseline HIV infection, but the CD4+ level measured at the time of switching to 2DR showed no difference between patients HbcAb-positive (683/mm3 [IQR 547–944]) and HbcAb-negative (680/mm3 [IQR 545–926]) (p = 0.91). The gene discussed is CD4; the disease is HIV infectious disease.