The multivariate Cox regression analysis of significant factors identified in the univariate analysis revealed that a baseline Ang2 level of ≥ 446 pg/mL was significantly associated with HCC recurrence after successful HCV eradication by DAAs (HR: 2.659, 95% CI: 1.209–5.847; p < 0.015). Here, ANGPT2 is linked to hepatocellular carcinoma.