The univariate Cox regression analysis showed that age ≥75 years, FIB-4 index ≥ 3.67, M2BPGi ≥ 1.89, AFP ≥ 4.6 ng/mL, Ang2 ≥ 402 pg/mL, and diabetes were significantly associated with HCC occurrence after successful HCV eradication by DAAs (Table 3). The gene discussed is AFP; the disease is diabetes mellitus.