The results indicated that age ≥75 years (hazard ratio (HR): 2.92, 95% confidence interval (CI): 1.34–6.33; p = 0.007, C-index:0.553) and baseline Ang2 level (HR: 2.75, 95% CI: 1.18–6.37; p = 0.019) were significantly associated with HCC occurrence after successful HCV eradication by DAAs. The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.