The multivariate Cox regression analysis revealed that Ang2 ≥ 402 pg/mL at the end of treatment alone was significantly associated with HCC occurrence after SVR by DAAs (HR: 3.68, 95% CI: 1.37–9.9; p < 0.01, C-index:0.55). This evidence concerns the gene ANGPT2 and hepatocellular carcinoma.