Finally, although the role of host genetics is unknown in this case, the role of interferon signaling and the renin–angiotensin system in COVID-19 is further supported by the observation that IFN-I-neutralizing [94] and AngII autoantibodies [95] can be detected in a significant portion of deceased and hospitalized COVID-19 patients, respectively. The gene discussed is AGT; the disease is COVID-19.