Moreover, we find that ERVWE1 results in neuroinflammation, which plays a major role in the neurobiology of schizophrenia [2,13], through increasing the production of nitric oxide (NO) [65], triggering a strong Cytotoxic T lymphocyte (CTL) activity [63], or increasing inflammatory markers including C-reactive protein (CRP) [13], interleukin 6 (IL-6) [13], tumour necrosis factor alpha (TNF-α) [64], and interleukin 10 (IL-10) [64]. Here, TNF is linked to schizophrenia.