RAC1 contributes to the pathogenic mechanism of schizophrenia as the downstream signaling central molecule of several schizophrenia risk genes [88], including disrupted-in-schizophrenia 1 (DISC1) [89] and brain-derived neurotrophic factor (BDNF) [88], which regulate neuroplasticity and neural connectivity. Here, BDNF is linked to schizophrenia.