That efforts to identify the interactants of the nsP3 protein were at the forefront of identifying alphaviral nsP P:P interactions, which is unsurprising; the prioritization of nsP3 was likely due to a combination of convenience and mystique, as the nsP3 protein is more forgiving to the inclusion of exogenous sequences and the functional importance of the nsP3 protein during infection has remained enigmatic for many years. Here, SH2D3C is linked to infection.