It has been demonstrated that the ZDHHC11 protein anchors to the endoplasmic reticulum (ER) and regulates the oligomerization of TRFA6 to induce the activation of NF-kB [15]; ZDHHC11 also promotes MITA-IRF3 interactions for facilitating the immune response following infections with DNA viruses [16]. The gene discussed is STING1; the disease is infection.