A previous study describing the humoral response during ZIKV infection of pregnant women with neonatal microcephaly, showed that amniotic fluid had increased levels of VEGF, pro-inflammatory cytokines (IL-8 and IL-6), and chemokines (IP-10 and MCP-1), which may contribute to other fetal developmental abnormalities [60]. The gene discussed is CCL2; the disease is Zika virus infectious disease.