MAPK1 dysregulation induces chorio-retinal atrophy and optic nerve abnormalities in ZIKV infections and STAT1/2 is involved in antiviral responses; in addition, ZIKV NS5 protein-mediated STAT2 degradation modulates type I and III interferon responses [51,67,68,69]. Here, STAT2 is linked to Zika virus infectious disease.