Still, the fact that the antiviral activity of LIF [51,52], IL-1β [53], and IL-6 [54,55] has been described previously in different in vitro and in vivo models for various human pathogens urges further research to understand the pleiotropic nature of these interleukins during viral infections, particularly during RABV-mediated encephalitis. This evidence concerns the gene IL6 and encephalitis.