TLR2 and liver disorder: Importantly, this group previously demonstrated that the TLR2 single nucleotide polymorphism (SNP) R753Q was associated with a higher degree of HCMV replication and liver disease [68] and then demonstrated in vitro in HEK-293 cells that this TLR2 SNP impaired the activation of NF-κB and subsequent regulation of these cytokines in response to gB [14].