Advanced disease is characterized by a hyper-inflammatory state, with high levels of circulating pro-inflammatory cytokines, such as Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) and interferon-gamma (IFN-γ) [5], which have been blamed for the extensive COVID-19-related tissue damage [6]. The gene discussed is IFNG; the disease is COVID-19.