In addition, Wan et al. also reported that Fcγ RIIb reduced the phosphorylation of TBK-1 and inhibited the expression of IFN-β by recruiting Src homology 2-containing inositol phosphatase-1 (SHIP-1) during the PRRSV-ADE infection [7]. The gene discussed is IFNB1; the disease is acute disseminated encephalomyelitis.