Mucin 1 (MUC1), a well-characterized TAA, is a transmembrane glycoprotein with normal expression on epithelial tissues which acts as a hydrator and moisturizer as well as a protective barrier on the cell surface, but is overexpressed and aberrantly glycosylated in malignantly transformed cells, and promotes the development and migration of cancer cells via participating in intracellular signaling pathways [96]. The gene discussed is MUC1; the disease is cancer.