-Proving that normal and IPF lung fibroblasts’ TFG-1-induced myofibroblastic differentiation is suppressed by hBM-MSCs-EVs and not by fibroblast EVs.-Evaluating cellular EVs uptaking kinetics, hBM-MSCs-EVs exhibit higher time- and dose-dependent cellular uptake compared to fibroblast EVs. Contrarily, Thy-1 removing or blocking as well as Thy-1-beta integrin interactions inhibiting reduced the hBM-MSCs-EVs uptake and thereby avoided suppressing of myofibroblastic differentiation. The gene discussed is THY1; the disease is idiopathic pulmonary fibrosis.