The diagnosis is based on three criteria: predisposition due to the presence of asthma or cystic fibrosis; the mandatory criterion, a positive skin test for Aspergillus or elevated IgE against A. fumigatus (total IgE > 1000 UI/mL); and finally, at least two of the three support criteria—recent eosinophil count in patients without the use of corticosteroids (>500 cell/L), radiographic characteristics of ABPA how the bronchiectasis, and serum precipitins or IgG against A. fumigatus [58,59]. The gene discussed is IGHE; the disease is bronchiectasis.