In a study published by Harris et al., in the TRAMP mouse model in which the tumors expressed the hemagglutinin antigen (HA), a recombinant vaccinia virus vaccine targeting the hemagglutinin antigen (Vacc-HA) in combination with stereotactic radiation therapy with three doses of 10 Gy augmented CD4+ T-cell responses to the tumor vaccine [112]. Here, CD4 is linked to neoplasm.