The results showed that CUR solid lipid NPs, CUR-loaded NPs, and CUR-loaded chitosan-alginate STPP NPs could effectively increase brain Bcl-2 family progenitors’ activation, P38 MAPK pathways activation, behavioral performance, klotho levels and EPO levels, as well as reduce neuronal apoptosis, neuronal OS, TNF-α mRNA levels, microglia inflammatory activation, and memory deficits among models of epilepsy. This evidence concerns the gene KL and epilepsy.