COL1A1 and Hepatic fibrosis: The authors of the included studies showed a reduction in AST, ALT, COL1A1 mRNA expression, hepatic fibrosis-related genes expression and hepatocytes, centrilobular vein and sinusoid capillaries collagen deposition, as well as increased hepatic albumin production, apoptosis of pro-inflammatory and pro-fibrotic cells, and HGF production levels.