Whilst initial efforts to eradicate melanoma lesions focused on eliminating CD20-positive melanoma cancer-initiating cells with CD20 antibody-conjugated vincristine-loaded liposomes [82], recent attention was directed towards the expression of melanoma antigen A1 [83] and the programmed death-ligand 1 (PD-L1) [84] in melanoma cells. This evidence concerns the gene CD274 and melanoma.