Over 16 weeks, 78 patients with mild to moderate AD were given a placebo or a daily supplement that contained 800 IU of vitamin E, 500 mg of vitamin C, 900 mg of alpha-lipoic acid, or 1200 mg of coenzyme Q. The researchers concluded that antioxidants had no effect on Aβ or tau levels. The gene discussed is MAPT; the disease is Alzheimer disease.