In vitro studies conducted with 125I-NM404 in PC-3 prostate cancer cells pretreated with Filipin III, an agent that sequesters cholesterol and thus disrupts membrane lipid raft integrity, resulted in a 40% reduction in 125I-NM404 uptake compared with untreated PC-3 cells, thus supporting the role of lipid membrane rafts in tumor accumulation of APC analogs [3]. Here, APC is linked to neoplasm.