WNT4 and hypertensive disorder: It was found that the expression level of miR-634 was reduced in the plasma of hypertensive patients, and miR-634 could target HASMCs through the Wnt/β-catenin signaling pathway and downregulate the expression of Wnt4, thereby inhibiting the proliferation and migration of HASMCs and influencing the course of hypertension by affecting vascular remodeling [116].