BCL2 and leukemia: For example, CD20/CD44 dual targeted siRNA delivery using layer-by-layer NPs (LbL NPs, PLGA/PLA/siRNA/PLA; PLGA, poly-(D,L-lactide-co-glycolide); PLA, poly-l-arginine) with BCL-2 siRNA in B cell lymphoma and leukemia cells downregulated BCL-2, induced apoptosis, and reduced the blood cancer cells.