TAMs-targeted imaging probes combine the existing imaging technology and TAM-targeted modification to target tumor-associated macrophages through the modification of mannose, polypeptide and polysaccharide against the receptors, such as CD206 (human mannose receptor), TREM2 (triggering receptor expressed on myeloid cells 2), legumain and scavenger receptor-A overexpressed by TAMs [15]. The gene discussed is TREM2; the disease is neoplasm.