223Ra, given at 4- or 10-Gy doses, increased the sensitivity of all previously mentioned cell lines to CTL-mediated lysis targeting the carcinoembryonic antigen (CEA; HLA-A2-restricted), mucin-1 (MUC-1; HLA-A2-restricted), and brachyury (HLA-A2/A24-restricted) tumor antigens [49]. The gene discussed is CEACAM5; the disease is neoplasm.