CD274 and colon adenocarcinoma: Employing both cold (unlabeled) anti-PD-L1 and 131I-anti-PD-L1, Wen et al. observed high tumor to normal tissue ratios of 131I-anti-PD-L1, and a significant survival benefit of combination therapy compared to control groups in MC38 and CT26 murine colon adenocarcinoma [71].